Peer-reviewed veterinary case report
Polyarginine induces an antitumor immune response through binding to toll-like receptor 4.
- Journal:
- Small (Weinheim an der Bergstrasse, Germany)
- Year:
- 2014
- Authors:
- Yang, Yong et al.
- Affiliation:
- Department of Nanomedicine · United States
Abstract
A novel function of polyarginine as an activator of the immune system is reported. Single-molecule fluorescence imaging and single-molecule force measurements demonstrate that polyarginine binds specifically to the toll-like receptor 4 (TLR4), inducing receptor dimerization and activation. Moreover, polyarginine induced immune activation inhibits tumor growth. These results suggest the potential use of polyarginine for cancer immunotherapy.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/24323884/