Peer-reviewed veterinary case report
Polycystic kidney disease in cats and how ultrasound compares
By Domanjko-Petric, Aleksandra et al.·Published in Journal of feline medicine and surgery·2008·Veterinary Faculty·View original on PubMed →
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Original publication title: Polycystic kidney disease: a review and occurrence in Slovenia with comparison between ultrasound and genetic testing.
- Species:
- cat
Plain-English summary
A group of cats, particularly Persian cats, were found to have polycystic kidney disease (PKD), which can lead to kidney failure later in life. In a study, 340 cats were examined, and 13.8% tested positive for PKD, with a striking 36% of Persian cats affected. The disease is characterized by multiple cysts in the kidneys, which can be detected using ultrasound or genetic testing. Genetic screening is becoming more common for diagnosing PKD, as it can identify the condition even before cysts form. Early detection is crucial for managing the health of affected cats.
People also search for: Persian cat kidney disease · PKD genetic testing for cats · cat kidney failure symptoms
Abstract
Polycystic kidney disease (PKD) is an inherited autosomal kidney disease which is most commonly identified in Persian and Persian related cats. Positive cats have multiple cysts of various sizes that occur in the renal cortex and medulla and occasionally in other abdominal organs. PKD often leads to renal failure which occurs from mid to late in life. Renal cysts can be diagnosed ultrasonographically after 7 weeks of age by an experienced ultrasonographer and a high resolution machine. However, ultrasonography is now being replaced by genetic screening. A total of 340 cats of variable breeds aged from 5 months to 18 years were ultrasonographically examined in the past 7 years at the University Veterinary Small Animal Clinic. Of these, 13.8% were PKD positive with very high prevalence in Persian cats (36%). There was no sex predilection identified. The C>A transversion at position 3284 on exon 29 of PKD1 gene, resulting in a stop mutation has been identified in the heterozygous state in eight affected cats examined (Persian breed). All heterozygous cats were also ultrasonographically positive.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/17988914/