Peer-reviewed veterinary case report
Polymer-Formulated Nerve Growth Factor Shows Effective Therapeutic Efficacy for Cerebral Microinfarcts.
- Journal:
- Advanced materials (Deerfield Beach, Fla.)
- Year:
- 2025
- Authors:
- Yan, Lingli et al.
- Affiliation:
- Institute of Chinese Medical Sciences · China
Abstract
Cerebral microinfarcts represent the most prevalent form of ischemic brain injury in the elderly, particularly among those suffering from dementia, Alzheimer's disease, and vascular risk factors. Despite their commonality, effective treatments have remained elusive. Herein, a novel treatment utilizing a polymer-formulated nerve growth factor capable of crossing the blood-brain barrier is reported, which effectively reduced oxidative stress and neuronal apoptosis, reshaped microglia polarization at infarct sites, and decreased the overall microinfarct burden, leading to notable improvements in behavioral and cognitive functions in a mouse model. This work provides a promising new avenue for the treatment of cerebral microinfarcts and other neurodegenerative diseases.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/39601176/