Peer-reviewed veterinary case report
Polymerase chain reaction-based detection of myc transduction in feline leukemia virus-infected cats.
- Journal:
- Archives of virology
- Year:
- 2018
- Authors:
- Sumi, Ryosuke et al.
- Affiliation:
- Joint Faculty of Veterinary Medicine · Japan
- Species:
- cat
Abstract
Feline lymphomas are associated with the transduction and activation of cellular proto-oncogenes, such as c-myc, by feline leukemia virus (FeLV). We describe a polymerase chain reaction assay for detection of myc transduction usable in clinical diagnosis. The assay targets c-myc exons 2 and 3, which together result in a FeLV-specific fusion gene following c-myc transduction. When this assay was conducted on FeLV-infected feline tissues submitted for clinical diagnosis of tumors, myc transduction was detected in 14% of T-cell lymphoma/leukemias. This newly established system could become a useful diagnostic tool in veterinary medicine.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/29353423/