Peer-reviewed veterinary case report
Polymorphisms in the 3'UTR of thegene associated with litter size in Ujimqin and Sonid sheep.
- Journal:
- Frontiers in veterinary science
- Year:
- 2025
- Authors:
- Zhang, Shuxin et al.
- Affiliation:
- School of Life Sciences · China
Abstract
Reproductive characteristics like ovulation frequency and litter number significantly impact the sheep industry. Transforming growth factor beta 1 () functions as a multifunctional regulator of key reproductive processes, plays a pivotal role in mammalian ovarian development. However, research on the role of thegene in the reproduction of Ujimqin and Sonid sheep breeds remains scarce. Thus, this study identified 11 new variants of thegene in these breeds by direct sequencing. In these 11 variants, the Sonid-linkage disequilibrium (LD)1 and Ujimqin-LD1 (comprising the g.50044287 G > A and g.50044526 G > C polymorphisms) in the 3' untranslated region of thegene were significantly associated with litter size in Sonid and Ujimqin ewes ( < 0.01, < 0.05, respectively), and the single g.50044837 C > T polymorphism in the 3'UTR was also associated with litter size in Sonid sheep ( < 0.01) through association analyses. These findings may provide potential genetic markers for improving prolificacy in sheep.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/41756017/