Peer-reviewed veterinary case report
Muscle disease after eye inflammation in a Jack Russell terrier
By Baiker, K et al.·Published in Journal of comparative pathology·2011·Department of Pathology and Infectious Diseases, United Kingdom·View original on PubMed →
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Original publication title: Polymyositis following Vogt-Koyanagi-Harada-like syndrome in a Jack Russell terrier.
- Species:
- dog
Plain-English summary
A 4-year-old male Jack Russell terrier developed painful eye problems, including inflammation and glaucoma, which led to the removal of both eyes. Three years later, he showed severe muscle weakness and skin issues, and unfortunately, his condition worsened quickly, leading to his humane euthanasia. A post-mortem examination revealed that he had an autoimmune disease affecting his muscles and skin, linked to the earlier eye condition. This case is notable as it is the first reported instance of muscle disease following this specific eye condition in a dog.
People also search for: Jack Russell terrier eye problems · dog muscle disease symptoms · autoimmune disease in dogs
Abstract
A male Jack Russell terrier developed bilateral uveitis and glaucoma at 1 year of age. Since the ocular disease was painful and unresponsive to treatment, both globes were enucleated. Microscopical evaluation of one enucleated globe revealed panuveitis, with pigment dispersion and phagocytosis consistent with the ocular lesions of canine Vogt-Koyanagi-Harada (VKH)-like syndrome. Three years later the dog was represented with severe muscle disease and skin lesions. Due to rapid clinical deterioration the dog was humanely destroyed. Necropsy examination revealed lichenoid interface inflammation in the skin and mucous membranes, with pigmentary incontinence consistent with VKH-like syndrome and lymphocytic and histiocytic polymyositis with marked muscle atrophy. Canine VKH-like syndrome is an autoimmune disease that targets melanocyte antigens. Some human patients with VKH disease develop additional autoimmune diseases. To our knowledge this is the first reported case of polymyositis subsequent to VKH-like disease in a dog. In addition, VKH-like disease has not been previously reported in a Jack Russell terrier.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/21129754/