Peer-reviewed veterinary case report
Nisin-biogel tested to control gum disease in dogs
By Eva Cunha et al.·Published in Antibiotics·2020·CIISA-Centro de Investigação Interdisciplinar em Sanidade Animal, Faculdade de Medicina Veterinária, Universidade de Lisboa, Av. da Universidade Técnica, 1300-477 Lisboa, Portugal, CH·View original on DOAJ →
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Original publication title: Polyphasic Validation of a Nisin-Biogel to Control Canine Periodontal Disease
- Species:
- dog
Plain-English summary
A study looked at a new gel containing nisin, which is a natural antimicrobial, to help control gum disease in dogs. Periodontal disease is common in dogs and can lead to serious health issues if not treated. The gel was tested to see how well it worked against bacteria found in dog mouths, and while it showed promise, it needed to be stored properly to maintain its effectiveness. The good news is that the gel was safe for use, showing no harmful effects on dog cells at certain concentrations. This research supports further testing in dogs to see how well the nisin-biogel can help with gum disease.
People also search for: dog gum disease treatment · canine periodontal disease gel · nisin for dogs dental health
Abstract
Background: Periodontal disease (PD) is a highly prevalent inflammatory disease in dogs. This disease is initiated by a polymicrobial biofilm on the teeth surface, whose control includes its prevention and removal. Recently, it was shown that nisin displays antimicrobial activity against canine PD-related bacteria. Moreover, guar gum biogel has shown to be a promising topical delivery system for nisin. Methods: In this study we aimed to evaluate the antimicrobial activity of the nisin-biogel in the presence of canine saliva and after a 24-month storage, at different conditions, using a canine oral enterococci collection. We also studied the nisin-biogel cytotoxicity using a Vero cell line and canine primary intestinal fibroblasts. Results: The presence of saliva hampers nisin-biogel antimicrobial activity, and higher nisin concentrations were required for an effective activity. A significant reduction (<i>p</i> ≤ 0.05) in inhibitory activity was observed for nisin-biogel solutions stored at 37 °C, over a 24-month period, which was not observed with the other conditions. The nisin-biogel showed no cytotoxicity against the cells tested at concentrations up to 200 µg/mL. Conclusions: Our results confirmed the potential of the nisin-biogel for canine PD control, supporting the development of an in vivo clinical trial.
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Search related cases →Original publication on DOAJ: https://doi.org/10.3390/antibiotics9040180