Peer-reviewed veterinary case report
How polyphenols and CBD affect dog skin allergy genes
By Massimini, Marcella et al.·Published in Frontiers in Veterinary Science·2021·View original on Crossref →
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Original publication title: Polyphenols and Cannabidiol Modulate Transcriptional Regulation of Th1/Th2 Inflammatory Genes Related to Canine Atopic Dermatitis
- Species:
- dog
Plain-English summary
A study looked at how a special mixture of natural ingredients, including flavonoids and cannabinoids, might help dogs with atopic dermatitis (a common skin allergy that causes itching). The researchers found that this mixture reduced the activity of certain genes linked to inflammation in skin cells and immune cells, which could help improve skin health. While this research is still in the early stages, it suggests that these natural compounds could be beneficial for managing skin allergies in dogs.
People also search for: dog itching treatment · natural remedies for dog skin allergies · canine atopic dermatitis supplements
Abstract
Canine atopic dermatitis (AD) is a multifactorial allergic disease associated with immune and abnormal skin barrier dysfunction and it is one of the primary causes of pruritus. Using a novel in vitro model of AD, here we tried to revert the alteration of transcriptional regulation of AD canine key genes testing a nutraceutical mixture containing flavonoids, stilbene, and cannabinoids, which are already well-known for their applications within dermatology diseases. The nutraceutical mixture induced in inflamed cells a significant downregulation (p < 0.05) of the gene expression of ccl2, ccl17, and tslp in keratinocytes and of ccl2, ccl17, and il31ra in monocytes. Consistent with the observed alterations of tslp, ccl2, ccl17, and il31ra messenger RNA (mRNA) levels, a significant increase (p < 0.05) of DNA methylation at specific CpG sites on the gene regulatory regions was found. These results lay the foundation for the use of these natural bioactives in veterinary medicine and provide a model for deeper understanding of their mechanisms of action, with potential translation to human research.
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Search related cases →Original publication on Crossref: https://doi.org/10.3389/fvets.2021.606197