Peer-reviewed veterinary case report
Genetic study of kneecap dislocation in Thai Pomeranian dogs
By Wangdee, C et al.·Published in Research in veterinary science·2017·Department of Veterinary Surgery, Netherlands·View original on PubMed →
PetCaseFinder translated the abstract of this peer-reviewed paper into plain English so pet owners can read it. We do not publish original research — every detail traces back to the citation above. How we work →
Original publication title: Population genetic analysis and genome-wide association study of patellar luxation in a Thai population of Pomeranian dogs.
- Species:
- dog
Plain-English summary
A group of Pomeranian dogs was studied to understand patellar luxation (PL), a condition where the kneecap slips out of place, causing limping or difficulty walking. Out of 339 dogs examined, 77% had PL, with most cases being bilateral (both knees affected). The research found that both male and female Pomeranians were equally at risk for this condition. Genetic analysis suggested that certain areas of their DNA might be linked to the development of PL. This information could help breeders make informed decisions to reduce the occurrence of this issue in future generations of Pomeranians.
People also search for: Pomeranian dog limping · patellar luxation treatment in dogs · Pomeranian knee problems · genetic testing for dog patellar luxation
Abstract
The genetics of patellar luxation (PL) were investigated in Pomeranian dogs presented at the Small Animal Hospital, Faculty of Veterinary Science, Chulalongkorn University. A cohort of 339 Pomeranian dogs, part of a four-generation pedigree of 842 Pomeranians, was screened for PL from 2006 to 2013. PL was present in 77% of the screened dogs, with 84% having bilateral and 16% unilateral luxation. Medial PL was more common (95%) than lateral PL (2%) or bidirectional PL (3%). The risk of PL was similar in male and female dogs (female:male relative risk 1.11, 95% CI 0.98-1.25). The heritability of PL in the screened population was 0.44±0.04 using a threshold model. A genome-wide association study of PL (48 cases and 48 controls) using a high-density SNP array indicated the possible involvement of 15 chromosomal regions, of which CFA05 and CFA32 remained associated in a larger study involving an additional 128 cases and 7 controls. Candidate genes in these regions may be involved in the pathogenesis of PL in Pomeranian dogs.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/28266317/