Peer-reviewed veterinary case report
Robenacoxib blood levels in dogs with osteoarthritis and dosing
By Fink, M et al.·Published in Research in veterinary science·2013·Novartis Pharma AG·View original on PubMed →
PetCaseFinder translated the abstract of this peer-reviewed paper into plain English so pet owners can read it. We do not publish original research — every detail traces back to the citation above. How we work →
Original publication title: Population pharmacokinetic analysis of blood concentrations of robenacoxib in dogs with osteoarthritis.
- Species:
- dog
Plain-English summary
A group of 208 dogs with chronic osteoarthritis (OA) were given a pain medication called robenacoxib at a dose of 1-2 mg per kilogram of body weight to see how well it worked. The study found that this dosage provided consistent pain relief across different dogs, regardless of their sex, age, or breed. The only factor that affected how the drug was processed in their bodies was their weight. Overall, the standard dosage appears to be effective for managing pain in dogs with OA, and no adjustments are needed for most patients.
People also search for: dog osteoarthritis treatment · robenacoxib dosage for dogs · pain relief for dogs with arthritis
Abstract
The purpose of this analysis was to investigate whether the recommended daily dosage of 1-2mg/kg robenacoxib provides consistent exposure when administered to dogs with chronic osteoarthritis (OA), and the need for dose adjustment in special patient populations. Data from three prospective, multi-center field studies in 208 OA dogs were analyzed using non-linear mixed effects modeling. A model based assessment was performed with stepwise inclusion and exclusion of population characteristics to explain between-subject variability, and assess the according necessity for dose adjustment. Only the influence of bodyweight on both apparent clearance and volume were found to be significant (p<0.01). No significant influence of sex, age and breed, or kidney and liver variables was identified in this representative sample of OA dogs. The population pharmacokinetic analysis performed showed that the 1-2mg/kg dosage chosen provided consistent robenacoxib exposure in a wide range of canine patients. No other dose adjustment seems necessary.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/23726662/