Peer-reviewed veterinary case report
How transdermal fentanyl works for pain in dogs after surgery
By Freise, K J et al.·Published in Journal of veterinary pharmacology and therapeutics·2012·Nexcyon Pharmaceuticals, United States·View original on PubMed →
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Original publication title: Population pharmacokinetics of transdermal fentanyl solution following a single dose administered prior to soft tissue and orthopedic surgery in dogs.
- Species:
- dog
Plain-English summary
A group of dogs undergoing orthopedic or soft tissue surgery received a new transdermal fentanyl solution (TFS) to help manage their pain after the procedure. This medication was applied a few hours before surgery, and it provided effective pain relief for several days afterward. The study found that the TFS worked well in maintaining steady levels of pain relief in the dogs, similar to results seen in healthy dogs during earlier tests. This means that TFS could be a good option for managing postoperative pain in dogs.
People also search for: dog surgery pain relief · transdermal fentanyl for dogs · postoperative pain management in dogs
Abstract
A novel, long-acting transdermal fentanyl solution (TFS) that delivers sustained plasma fentanyl concentrations following a single application for the control of postoperative pain has recently been approved for use in dogs. The pharmacokinetics (PKs) of this formulation have been evaluated in healthy laboratory dogs, but they have not been reported in a clinical population of dogs for which it is indicated. Plasma fentanyl concentrations were determined from 215 dogs following a single, small-volume (∼50 μL/kg) dose of TFS administered 2-4 h prior to orthopedic or soft tissue surgery. A population PK model was fit, and a 1-compartment open PK model with first-order absorption and an absorption lag-time best described the data. No tested clinical covariates had a significant effect on the PKs. The final model adequately described the population PKs and gave results consistent with laboratory PK studies in healthy dogs. The PKs were primarily characterized by a rapid initial increase in plasma fentanyl concentrations and a long terminal half-life of 74.0 (95% C.I. [54.7-113]) h governed by flip-flop kinetics for the typical subject. The plasma fentanyl concentrations were sustained over days in the range considered to be analgesic for postoperative pain in dogs.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/22731777/