Peer-reviewed veterinary case report
Neonatal GnRH treatment delays puberty in dogs until over 70 weeks
By Faya, M et al.·Published in Theriogenology·2018·Catholic University of Có·View original on PubMed →
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Original publication title: Postponement of canine puberty by neonatal administration of a long term release GnRH superagonist.
- Species:
- dog
Plain-English summary
A group of 24 puppies received a treatment called deslorelin to see if it could delay the onset of puberty. The puppies that got the deslorelin started showing signs of puberty much later than those that received a placebo. While the females had no side effects and were able to conceive when mated, two of the males treated with deslorelin developed a condition called cryptorchidism, where the testicles do not descend properly. Overall, deslorelin effectively postponed puberty in these puppies without causing significant issues for the females.
People also search for: puppy puberty delay treatment · deslorelin for dogs · cryptorchidism in male puppies
Abstract
The objective of this study was to assess the efficiency and clinical safety of postnatal administration of a GnRH agonist on canine puberty postponement. Sexual steroids and histological gonadal changes were also described. Twenty-four littermate puppies were randomly assigned to: Deslorelin acetate 18.8 mg sc (DESLO; n = 12) or Placebo: sc (PLACE; n = 12) postnatally. The dogs were clinically and endocrinologically followed up until puberty when they were gonadectomized and their gonads histomorphometrically studied. Deslorelin postponed the age of puberty (72.7 ± 4.8 vs. 35.8 ± 1.9 weeks; P < 0.01) in these dogs. At the time of this submission, 3 DESLO dogs (108 weeks old) remain non-pubertal. All dogs concluded growing at a similar age (29.75 ± 2.44 vs. 29.25 ± 0.90 weeks; P > 0.1) independently of their group and pubertal status. None of the females had side effects while the 2 non pubertal DESLO males presented bilateral cryptorchydism. All the bitches ovulated at puberty (P > 0.1) and the 2 DESLO that were mated became pregnant. Deslorelin postponed basal serum sexual steroids up to puberty in both genders (P < 0.01). The histomorphometrical study of the testes revealed that the tubular diameter (P < 0.05), germinal epithelium height and composition (P < 0.01) were decreased in DESLO group. Ovarian structures did not differ between treatments (P > 0.05). It was concluded that postnatal deslorelin decreased sexual steroids reversibly postponing puberty in both genders without side effects in bitches and causing 2/6 of cryptorchydism and impairment of testicular histomorphometry in male dogs.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/29913424/