Peer-reviewed veterinary case report
Potent and selective biphenyl azole inhibitors of adipocyte fatty acid binding protein (aFABP).
- Journal:
- Bioorganic & medicinal chemistry letters
- Year:
- 2007
- Authors:
- Sulsky, Richard et al.
- Affiliation:
- Department of Metabolic Disease Chemistry · United States
Abstract
Herein we report the first disclosure of biphenyl azoles that are nanomolar binders of adipocyte fatty acid binding protein (aFABP or aP2) with up to thousand-fold selectivity against muscle fatty acid binding protein and epidermal fatty acid binding protein. In addition a new radio-ligand to determine binding against the three fatty acid binding proteins was also synthesized.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/17502136/