Peer-reviewed veterinary case report
Potential applications for antiviral therapy and prophylaxis in bovine medicine.
- Journal:
- Animal health research reviews
- Year:
- 2014
- Authors:
- Newcomer, Benjamin W et al.
- Affiliation:
- Department of Pathobiology · United States
Plain-English summary
Viral diseases are a big problem for cattle, causing both suffering for the animals and financial losses for farmers. Factors like increased trade, larger herds, urban growth, and climate changes have allowed viruses to spread to areas where they weren't previously found, putting unprotected cattle at risk. Although there are no antiviral medications currently approved for use in cattle, researchers are making progress in developing treatments for specific viruses like bovine viral diarrhea virus (BVDV), foot and mouth disease virus (FMDV), and bovine herpesvirus (BHV). Some promising antiviral compounds have been identified and tested, but they are not yet available for commercial use. Overall, while there is hope for future antiviral treatments in cattle, they are still in the development phase.
Abstract
Viral disease is one of the major causes of financial loss and animal suffering in today's cattle industry. Increases in global commerce and average herd size, urbanization, vertical integration within the industry and alterations in global climate patterns have allowed the spread of pathogenic viruses, or the introduction of new viral species, into regions previously free of such pathogens, creating the potential for widespread morbidity and mortality in naïve cattle populations. Despite this, no antiviral products are currently commercially licensed for use in bovine medicine, although significant progress has been made in the development of antivirals for use against bovine viral diarrhea virus (BVDV), foot and mouth disease virus (FMDV) and bovine herpesvirus (BHV). BVDV is extensively studied as a model virus for human antiviral studies. Consequently, many compounds with efficacy have been identified and a few have been successfully used to prevent infection in vivo although commercial development is still lacking. FMDV is also the subject of extensive antiviral testing due to the importance of outbreak containment for maintenance of export markets. Thirdly, BHV presents an attractive target for antiviral development due to its worldwide presence. Antiviral studies for other bovine viral pathogens are largely limited to preliminary studies. This review summarizes the current state of knowledge of antiviral compounds against several key bovine pathogens and the potential for commercial antiviral applications in the prevention and control of several selected bovine diseases.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/24810855/