Peer-reviewed veterinary case report
Chloramphenicol dosing for dog urinary tract infections
By KuKanich, Kate S et al.·Published in Journal of veterinary pharmacology and therapeutics·2024·Department of Clinical Sciences, United States·View original on PubMed →
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Original publication title: Potential for extending the chloramphenicol dosing interval for canine urinary tract infections.
- Species:
- dog
Plain-English summary
A study looked at how well the antibiotic chloramphenicol works for treating urinary tract infections in dogs. Healthy dogs, including Beagles and other breeds, were given a single dose of the medication, and their urine was tested to see how much of the drug was present over time. The results showed that while Beagles had lower levels of the drug in their urine, other breeds maintained effective levels for longer. This suggests that most dogs could potentially be treated with chloramphenicol every 12 hours instead of every 8 hours, but more research is needed to confirm this.
People also search for: dog urinary tract infection treatment · chloramphenicol dosage for dogs · Beagle urinary tract infection medication
Abstract
Canine urinary excretion of chloramphenicol was evaluated to optimize a dosing protocol for treating urinary tract infections. Seven healthy male intact purpose-bred Beagles and six healthy client-owned dogs of various breeds each received a single oral 50 mg/kg dose of chloramphenicol. Urine was collected at baseline, and 6, 8, 12, and 24 h after chloramphenicol. Chloramphenicol urine concentrations were measured and compared to the epidemiological cutoff value for E. coli (16 mcg/mL). At 8 h, mean chloramphenicol concentration from all dogs was 266.9 mcg/mL (90% CI 136.2-397.7 mcg/mL) but was lower in Beagles than client-owned dogs. At 12 h, mean chloramphenicol concentration from all dogs was 111.0 mcg/mL (90% CI 36.9-185.0 mcg/mL) and was lower in Beagles (10.6 mcg/mL, 90% CI 1.4-19.8 mcg/mL) than client-owned dogs (228.0 mcg/mL, 90% CI 103.0-353.1 mcg/mL). Urine half-life was similar for all dogs (1.8-3.8 h). This justifies dosing chloramphenicol 50 mg/kg PO q 8 h. All client-owned dogs additionally maintained concentrations well above 16 mcg/mL, for 12 h, suggesting that q 12-h dosing might be appropriate for non-Beagle dogs with susceptible lower urinary tract infections. A clinical trial in dogs with urinary tract infections is needed as well as further investigation into potential breed differences.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/39158199/