Peer-reviewed veterinary case report
Pradofloxacin compared to amoxycillin for treating deep skin
By Mueller, Ralf S & Stephan, Bernd·Published in Veterinary dermatology·2007·Small Animal Clinic, Germany·View original on PubMed →
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Original publication title: Pradofloxacin in the treatment of canine deep pyoderma: a multicentred, blinded, randomized parallel trial.
- Species:
- dog
Plain-English summary
A group of dogs with deep skin infections (deep pyoderma) were treated with either pradofloxacin or a combination of amoxicillin and clavulanic acid to see which worked better. The dogs were monitored for improvement in their skin lesions and overall condition over several weeks. Out of 56 dogs treated with pradofloxacin, 86% showed significant improvement and none had a recurrence of symptoms after treatment. In comparison, 73% of the 51 dogs treated with the antibiotic combination improved, but some experienced a return of symptoms shortly after stopping treatment. This suggests that pradofloxacin is an effective option for treating deep pyoderma in dogs.
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Abstract
A multicentre, randomized, blinded study compared the efficacy of pradofloxacin with that of a combination of amoxycillin/clavulanic acid in the treatment of deep pyoderma in dogs. Dogs with clinical lesions of deep pyoderma and a positive bacterial culture were included in the study. At each visit, they were evaluated with lesion, pruritus and general condition scores. Dogs were treated either with pradofloxacin at 3 mg kg-1 once daily or with amoxycillin at 10 mg kg-1 and clavulanic acid at 2.5 mg kg-1 twice daily and evaluated weekly for 3 weeks and every 2 weeks thereafter until 2 weeks past clinical remission. Maximal treatment duration was 9 weeks, and maximal evaluation period was 11 weeks. Of the 56 dogs treated with pradofloxacin (group 1), 48 dogs (86%) achieved clinical remission, four dogs improved, four dogs did not respond and a recurrence of clinical signs was not seen in any patient after 11 weeks. Of the 51 dogs treated with amoxycillin/clavulanic acid (group 2), 37 dogs achieved clinical remission (73%), three dogs showed improvement, five dogs showed no response and in six dogs, clinical signs recurred within 2 weeks of cessation of therapy. These results indicate that pradofloxacin is an efficacious therapy comparable to amoxycillin/clavulanic acid for deep bacterial pyoderma in dogs.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/17470228/