Peer-reviewed veterinary case report
Preclinical Mouse Metastatic Model Established Through Induced Lung Metastases.
- Journal:
- Methods in molecular biology (Clifton, N.J.)
- Year:
- 2024
- Authors:
- Uršič Valentinuzzi, Katja et al.
- Affiliation:
- Department of Experimental Oncology
Abstract
Metastatic disease is the major cause of cancer death, and the lung is one of the most common sites of cancer metastases. To investigate systemic antitumor effects or protective potential of local therapies, mouse models with induced metastases are indispensable in preclinical cancer research. Here, we describe the protocol for the metastatic mouse model established through induced 4T1 mammary carcinoma metastases. With minor prior optimization, it can be applied to other tumor cell lines of interest.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/38236538/