Peer-reviewed veterinary case report
Predicting outcomes after radioiodine treatment for hyperthyroid cats
By Peterson, Mark E & Rishniw, Mark·Published in Journal of veterinary internal medicine·2022·Animal Endocrine Clinic, United States·View original on PubMed →
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Original publication title: Predicting outcomes in hyperthyroid cats treated with radioiodine.
- Species:
- cat
Plain-English summary
A group of hyperthyroid cats were treated with radioiodine, which is a common therapy for this condition. After treatment, some cats continued to have high thyroid hormone levels, while others developed low thyroid hormone levels due to the treatment. Researchers found that older female cats with certain thyroid characteristics were more likely to develop low thyroid hormone levels, while younger cats with more severe symptoms were more likely to remain hyperthyroid. Understanding these factors can help veterinarians predict how well a cat might respond to radioiodine treatment.
People also search for: cat hyperthyroidism treatment · radioiodine for cats · signs of low thyroid in cats
Abstract
BACKGROUND: Radioiodine (I) is the treatment of choice for cats with hyperthyroidism. AfterI, however, euthyroidism is not always achieved, with 5% to 10% of cats remaining persistently hyperthyroid and 20% to 50% developing iatrogenic hypothyroidism. OBJECTIVES: To identify pretreatment factors that may help predict persistent hyperthyroidism and iatrogenic hypothyroidism after treatment of cats using a novelI dosing algorithm. ANIMALS: One thousand and four hundred hyperthyroid cats treated withI. METHODS: Prospective, before-and-after study. Pretreatment predictors (clinical, laboratory, scintigraphic,I dose,I uptake measurements) of treatment failure or iatrogenic hypothyroidism were identified by multivariable logistic regression analysis. RESULTS: Cats that developed iatrogenic hypothyroidism were more likely to be older (odds ratio [OR] = 1.10; 95% confidence interval [CI], 1.04-1.17; P = .001), female (OR = 2.04; 95% CI, 1.54-2.70; P < .001), have detectable serum thyroid-stimulating hormone (TSH) concentrations (OR = 4.19; 95% CI, 2.0-8.81; P < .001), have bilateral thyroid nodules (OR = 1.57; 95% CI, 1.19-2.08; P < .001), have homogeneous, bilateral distribution ofTc-pertechnetate uptake (OR = 2.93; 95% CI, 2.05-4.19; P < .001), have milder severity score (OR = 0.62; 95% CI, 0.49-0.79; P < .001), and have higherI uptake (OR = 2.40; 95% CI, 1.75-3.28; P < .001). In contrast, cats remaining persistently hyperthyroid were more likely to be younger (OR = 0.81; 95% CI, 0.72-0.92; P < .001), have higher severity score (OR = 1.87; 95% CI, 1.51-2.31; P < .001), and have lowerI uptake (OR = 3.50; 95% CI, 1.8-6.80; P < .001). CONCLUSIONS AND CLINICAL IMPORTANCE: Age, sex, serum TSH concentration, bilateral and homogeneousTc-pertechnetate uptake on scintigraphy, severity score, and percentI uptake are all factors that might help predict outcome ofI treatment in hyperthyroid cats. Cats with persistent hyperthyroidism had many predictive factors that directly contrasted those of cats that developedI-induced hypothyroidism.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/34817910/