Peer-reviewed veterinary case report
Predicting first heart failure in dogs with mitral valve disease
By Reynolds, Caryn A et al.·Published in Journal of veterinary cardiology : the official journal of the European Society of Veterinary Cardiology·2012·Department of Clinical Studies-Philadelphia, United States·View original on PubMed →
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Original publication title: Prediction of first onset of congestive heart failure in dogs with degenerative mitral valve disease: the PREDICT cohort study.
- Species:
- dog
Plain-English summary
A group of dogs with degenerative mitral valve disease (DMVD) were studied to find out which factors could predict the first signs of congestive heart failure (CHF). Researchers discovered that measuring the size of the heart and the level of a specific protein in the blood (NT-proBNP) could help identify dogs at risk for developing CHF. In fact, they found that these tests could accurately predict the onset of CHF in about 69% of cases. This information can be useful for veterinarians in managing dogs with DMVD to help prevent or address heart failure early.
People also search for: dog heart failure symptoms · degenerative mitral valve disease in dogs · NT-proBNP test for dogs
Abstract
OBJECTIVE: To identify risk factors for first-onset congestive heart failure (CHF) in dogs with degenerative mitral valve disease (DMVD). ANIMALS: Eighty-two dogs with and without CHF secondary to DMVD were retrospectively assigned to a derivation cohort. Sixty-five dogs with asymptomatic DMVD were recruited into a prospective validation cohort. METHODS: Variables associated with risk of CHF in dogs were identified in a derivation cohort and used to construct a predictive model, which was then prospectively tested through longitudinal examination of a validation cohort. RESULTS: Logistic regression analysis of the derivation cohort yielded a predictive model that included the left atrial to aortic root dimension ratio (LA:Ao) and plasma concentration of N-terminal pro-B-type natriuretic peptide (NT-proBNP). When this model was prospectively applied to the validation cohort, it correctly predicted first-onset of CHF in 69.2% of cases. Analysis of the validation cohort revealed that plasma NT-proBNP concentration and indexed left ventricular end-diastolic diameter (LVIDd:Ao) were independent risk factors for development of first-onset CHF in dogs with DMVD (NT-proBNP ≥ 1500 pmol/L, odds ratio (OR), 5.76, 95% confidence interval (CI), 1.37-24.28, P = 0.017; LVIDd:Ao ≥ 3, OR, 6.11, 95% CI, 1.09-34.05, P = 0.039). CONCLUSIONS: Measures of left heart size and plasma NT-proBNP concentration independently estimate risk of first-onset of CHF in dogs with DMVD. These parameters can contribute to the management of dogs with DMVD.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/22366568/