Peer-reviewed veterinary case report
What affects how fast canine transmissible venereal tumor shrinks
By Scarpelli, Karime C et al.·Published in Veterinary journal (London, England : 1997)·2010·Faculty of Medical Sciences, Brazil·View original on PubMed →
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Original publication title: Predictive factors for the regression of canine transmissible venereal tumor during vincristine therapy.
- Species:
- dog
Plain-English summary
A group of 100 dogs with a transmissible venereal tumor (a type of cancer) were treated with vincristine, a chemotherapy drug, to see how long it took for the tumors to disappear. The study found that larger tumors, older dogs, and those treated during hot and rainy months took longer to respond to the treatment. Interestingly, factors like the dog's sex, weight, or breed didn't seem to affect how quickly the tumors shrank. This research suggests that some dogs may have a slower response to treatment based on their individual circumstances, and more studies are needed to understand why.
People also search for: dog cancer treatment vincristine · canine transmissible venereal tumor symptoms · why is my dog taking longer to recover from cancer
Abstract
Canine transmissible venereal tumor (CTVT) is a neoplasm transmitted by transplantation. Monochemotherapy with vincristine is considered to be effective, but treatment time until complete clinical remission may vary. The aim of this study was to determine which clinical data at diagnosis could predict the responsiveness of CTVT to vincristine chemotherapy. One hundred dogs with CTVT entered this prospective study. The animals were treated with vincristine sulfate (0.025 mg/kg) at weekly intervals until the tumor had macroscopically disappeared. The time to complete remission was recorded. A multivariate Cox regression model indicated that larger tumor mass, increased age and therapy during hot and rainy months were independent significant unfavorable predictive factors retarding remission, whereas sex, weight, status as owned dog or breed were of no predictive relevance. Further studies are necessary to investigate whether these results are due to changes in immunological response mechanisms in animals with a diminished immune surveillance, resulting in delays in tumor regression.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/19109042/