Peer-reviewed veterinary case report
How natriuretic peptides predict mitral valve disease in Cavalier
By Tarnow, Inge et al.·Published in Veterinary journal (London, England : 1997)·2009·Department of Basic Animal and Veterinary Sciences·View original on PubMed →
PetCaseFinder translated the abstract of this peer-reviewed paper into plain English so pet owners can read it. We do not publish original research — every detail traces back to the citation above. How we work →
Original publication title: Predictive value of natriuretic peptides in dogs with mitral valve disease.
- Species:
- dog
Plain-English summary
A group of Cavalier King Charles Spaniels with heart issues were tested for two specific proteins (NT-proANP and NT-proBNP) to see if they could help diagnose early heart disease. The study found that dogs with more severe mitral valve problems had higher levels of these proteins compared to healthier dogs. Additionally, dogs showing signs of heart failure had very high levels of these proteins. The results suggest that measuring these proteins can help predict how the heart condition might worsen over time.
People also search for: Cavalier King Charles Spaniel heart disease symptoms · dog heart failure treatment · NT-proBNP test for dogs
Abstract
Natriuretic peptides are useful in diagnosing heart failure in dogs. However, their usefulness in detecting early stages of myxomatous mitral valve disease (MMVD) has been debated. This study evaluated N-terminal (NT) fragment pro-atrial natriuretic peptide (NT-proANP) and NT-pro-brain natriuretic peptide (NT-proBNP) in 39 Cavalier King Charles Spaniels (CKCS) with pre-clinical mitral valve regurgitation (MR), sixteen dogs with clinical signs of heart failure (HF) and thirteen healthy control dogs. Twenty seven CKCS and ten control dogs were re-examined 4 years after the initial examination and the status of the dogs 5 years after the initial examination was determined by telephone calls to the owner. All dogs were evaluated by clinical examination and echocardiography. CKCS with severe MR had higher NT-proANP and NT-proBNP compared to controls and CKCS with less severe MR. Dogs with clinical signs of HF had markedly elevated NT-proANP and NT-proBNP. Plasma concentrations of the natriuretic peptides measured at re-examination could predict progression in regurgitant jet size.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/18675567/