Peer-reviewed veterinary case report
Prefrontal dysfunction and a monkey model of schizophrenia.
- Journal:
- Neuroscience bulletin
- Year:
- 2015
- Authors:
- Mao, Ping et al.
- Affiliation:
- Kunming General Hospital of Chengdu Military Command · China
Abstract
The prefrontal cortex is implicated in cognitive functioning and schizophrenia. Prefrontal dysfunction is closely associated with the symptoms of schizophrenia. In addition to the features typical of schizophrenia, patients also present with aspects of cognitive disorders. Based on these relationships, a monkey model mimicking the cognitive symptoms of schizophrenia has been made using treatment with the non-specific competitive N-methyl-D-aspartate receptor antagonist, phencyclidine. The symptoms are ameliorated by atypical antipsychotic drugs such as clozapine. The beneficial effects of clozapine on behavioral impairment might be a specific indicator of schizophrenia-related cognitive impairment.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/25822218/