Peer-reviewed veterinary case report
Dog with neurological signs diagnosed with prekallikrein deficiency
By Okawa, Takumi et al.·Published in The Journal of veterinary medical science·2011·Department of Veterinary Medicine, Japan·View original on PubMed →
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Original publication title: Prekallikrein deficiency in a dog.
- Species:
- dog
Plain-English summary
A 5-year-old mixed-breed dog was brought in for neurological issues and showed abnormal blood clotting results. The vet found that the dog had a specific deficiency in a protein called prekallikrein, which is important for blood clotting. This condition was confirmed using a special blood test. The dog had a genetic mutation that caused this deficiency, which is the first time this has been reported in dogs. While the case highlights a rare condition, the outcome for the dog wasn't detailed in the report.
People also search for: dog neurological problems · dog blood clotting issues · prekallikrein deficiency in dogs
Abstract
Prekallikrein (PK) deficiency is an uncommon disorder in dogs. In this report, we describe a case of a dog that was referred for neurological defects and had a prolonged activated partial thromboplastin time (aPTT) and normal prothrombin time (PT) with no hemostatic defects. By using human PK-deficient plasma, the dog was diagnosed to have PK deficiency. The nucleotide sequence of normal canine PK cDNA was determined and compared with the genomic sequences of PK in the affected dog. The comparison revealed that the dog had a point mutation in exon 8 that leads to an amino acid substitution in the fourth apple domain of PK. This is the first report showing a point mutation of PK in a dog with PK deficiency.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/20736516/