High heart protein levels in dogs with sudden stroke

Abstract

OBJECTIVES: To describe the incidence of elevated serum cardiac troponin I in dogs with acute ischaemic strokes, to evaluate its prognostic value in these patients and characterise a possible relationship between cardiac troponin I elevation in dogs with ischaemic strokes and underlying cardiac dysfunction. MATERIALS AND METHODS: Prospective study of 18 dogs with acute ischaemic stroke diagnosed by MRI of the brain. Serum cardiac troponin I concentration, trans-thoracic echocardiography and six-lead electrocardiography were performed and findings were compared between dogs with good and poor outcome. RESULTS: Serum cardiac troponin I was increased in 17 dogs (median 0.95 ng/mL; range 0.146 to 153). Focal hyperechoic regions of myocardium were visible in two dogs using trans-thoracic echocardiography and presumed to represent acute infarcts. A significant association was found between cardiac troponin I and creatinine concentrations. No difference in cardiac troponin I concentrations was detected between dogs that experienced good and poor outcomes. Clinically important cardiac dysfunction was identified in two dogs. CLINICAL SIGNIFICANCE: Cardiac troponin I is commonly elevated in patients diagnosed with acute ischaemic stroke but, in this small study population, did not have prognostic value. Larger studies (recruiting a study population of 98 dogs for a power of 0.8 and a 0.05 alpha/critical value) would aid in further investigation of these preliminary results.