Peer-reviewed veterinary case report
Photodynamic therapy with surgery for prostate cancer in dogs
By L'eplattenier, H F et al.·Published in Veterinary journal (London, England : 1997)·2008·Utrecht University, Netherlands·View original on PubMed →
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Original publication title: Preliminary results of intraoperative photodynamic therapy with 5-aminolevulinic acid in dogs with prostate carcinoma.
- Species:
- dog
Plain-English summary
Six dogs with prostate cancer underwent surgery and received a special light therapy during the procedure, along with a pain medication called meloxicam. Unfortunately, the treatment did not improve their condition significantly, as the cancer continued to grow and caused symptoms like difficulty urinating. The average survival time after treatment was about 41 days. The researchers believe that the light used during therapy didn't penetrate the tissue deeply enough to be effective, suggesting that different methods of delivering light might work better in the future.
People also search for: dog prostate cancer treatment · signs of prostate cancer in dogs · meloxicam for dogs with cancer
Abstract
Six client-owned dogs with prostate carcinoma were treated with a combination of (1) partial subcapsular prostatectomy using an Nd:YAG laser, (2) intraoperative photodynamic therapy using a halogen broad band lamp after local administration of a photosensitiser, and (3) systemic treatment with meloxicam. Median survival time was 41days (range 10-68days), which compared negatively with previous reports of subtotal laser prostatectomy combined with topical interleukin-2 administration, and photodynamic therapy alone. Despite treatment, the disease progressed locally, causing signs of stranguria to recur, and in the form of distant metastases. The recurrence of clinical signs due to the primary tumour despite photodynamic therapy is probably largely explained by insufficient penetration of light into the tissue. Better results may be obtained using other light sources (e.g. laser) and alternative techniques of light delivery, such as fibres or catheters allowing interstitial diffusion of light.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/17904397/