Peer-reviewed veterinary case report
New protamine zinc insulin tested for treating diabetes in cats
By Norsworthy, Gary et al.·Published in Veterinary therapeutics : research in applied veterinary medicine·2009·Alamo Feline Health Center, United States·View original on PubMed →
PetCaseFinder translated the abstract of this peer-reviewed paper into plain English so pet owners can read it. We do not publish original research — every detail traces back to the citation above. How we work →
Original publication title: Preliminary study of protamine zinc recombinant insulin for the treatment of diabetes mellitus in cats.
- Species:
- cat
Plain-English summary
Fifty cats with diabetes were switched from a common insulin treatment to a new formulation called protamine zinc recombinant insulin (PZIR) for 30 days. The goal was to see if PZIR could control blood sugar levels just as well as the previous treatment. The cats were monitored closely, and only one had a low blood sugar episode, which was managed by removing that cat from the study. At the end of the study, the cats showed no significant changes in weight or blood sugar control, suggesting that PZIR is just as effective as the traditional insulin treatment.
People also search for: cat diabetes treatment options · insulin for diabetic cats · symptoms of low blood sugar in cats
Abstract
The efficacy of a new protamine zinc formulation based on recombinant insulin (PZIR) was compared with a veterinary-approved beef/pork-source insulin (PZI VET, Idexx Pharmaceuticals) that has been shown to significantly decrease blood glucose in cats with diabetes mellitus (DM). After being examined and weighed and having blood collected for determination of serum fructosamine concentrations, 50 cats with DM and stable glycemic control on PZI VET were switched to PZIR for 30 days at the same dose rate and interval. There was only one reported episode of hypoglycemia, and the cat was withdrawn from the study. In the 47 cats completing the study, there were no significant differences in body weight or serum fructosamine concentrations at days 15 or 30 compared with day 0. The results of this study indicate that PZIR provides glycemic control that is comparable to that of PZI VET when used at the same dose and dosing interval.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/19742445/