Peer-reviewed veterinary case report
Urinary protein signals worsening kidney disease in cats
By Watanabe, Akiko et al.·Published in Canadian journal of veterinary research = Revue canadienne de recherche veterinaire·2021·Graduate School of Veterinary Sciences, Japan·View original on PubMed →
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Original publication title: Preliminary study of urinary excretion of liver-type fatty acid-binding protein in a cat model of chronic kidney disease.
- Species:
- cat
Plain-English summary
Two cats with chronic kidney disease (CKD) were studied to see if a specific protein in their urine could help predict worsening kidney function. In one cat, the level of this protein increased before other common kidney tests showed any problems, indicating that it might be a useful early warning sign. The other cat's protein levels stayed low, suggesting its kidney function was stable. This research suggests that monitoring this urinary protein could help veterinarians track CKD progression in cats more effectively.
People also search for: cat kidney disease symptoms · chronic kidney disease in cats · early signs of kidney problems in cats
Abstract
Urinary liver-type fatty acid-binding protein (uL-FABP) is a clinically useful biomarker for monitoring chronic kidney disease (CKD) in humans. However, long-term monitoring of uL-FABP in CKD cats has not been reported. The objective of this preliminary study was to investigate whether the urinary excretion of L-FABP could predict the deterioration of renal function in 2 CKD model cats. Urinary liver-type fatty acid-binding protein (uL-FABP) increased before standard renal biomarkers, including serum creatinine, blood urea nitrogen, and symmetric dimethylarginine, in 1 cat with deteriorating renal function, but remained low and relatively stable in another cat with stable renal function. Our results suggest that uL-FABP is a potential clinical biomarker for predicting the progression of CKD in cats, as it is in humans.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/33883825/