Peer-reviewed veterinary case report
Acetazolamide premedication does not reduce pain after dog
By Tavares, Inês T et al.·Published in Veterinary medicine and science·2023·Faculty of Veterinary Medicine·View original on PubMed →
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Original publication title: Premedication with acetazolamide: Is its use for postoperative pain and stress control after laparoscopic ovariectomy in dogs ruled out?
- Species:
- dog
Plain-English summary
A group of 30 mixed-breed female dogs underwent laparoscopic ovariectomy (a minimally invasive surgery to remove the ovaries) to see if premedicating with acetazolamide could help reduce pain after the procedure. The dogs were divided into three groups: one had traditional surgery, one had laparoscopic surgery without acetazolamide, and one had laparoscopic surgery with acetazolamide given beforehand. While the dogs that had laparoscopic surgery generally experienced less pain than those that had open surgery, the addition of acetazolamide did not significantly lower pain scores compared to those without it. More research is needed to determine if acetazolamide should be used for pain management in these cases.
People also search for: dog laparoscopic ovariectomy pain management · acetazolamide for dogs · post-surgery pain relief for dogs
Abstract
BACKGROUND: Studies in human medicine have concluded that acetazolamide reduces pain associated with carbon dioxide insufflation during laparoscopic surgery. However, there are no published reports regarding the use of acetazolamide for this purpose in companion animals, despite the increasing popularity of laparoscopic techniques in veterinary medicine due to their advantages over open surgeries. OBJECTIVES: Thirty mixed-breed female dogs were included in the study and randomly assigned to one of three groups: OVE (median celiotomy ovariectomy; n = 10), OVEL (laparoscopic ovariectomy, n = 10) and OVELA (laparoscopic ovariectomy with acetazolamide preoperative administration; n = 10). Experienced surgeons performed all procedures, and the anaesthetic and analgesic protocols were identical for all animals. Acetazolamide was administered orally (at a dose of 25 mg/kg) 2 h prior to induction in the OVELA group. Postoperative pain was evaluated using serum cortisol, salivary cortisol, and the University of Melbourne Pain Scale (UMPS) Score. RESULTS: Any statistical differences were observed in the UMPS scores when the OVELA group was compared to the OVEL group at 1 h after surgery (p = 0.515), 12 h (p = 0.375) and 24 h (p = 0.242). Animals undergoing open surgery (OVE group) had significantly higher pain scores at all times after surgery when compared with OVEL and OVELA groups. A high positive correlation (r = 0.792; p = 0.01) was found between serum and saliva cortisol concentrations. Mean saliva cortisol concentration was not significantly lower for the OVELA group compared to the other groups. CONCLUSIONS: This study found evidence that preoperative administration of acetazolamide may be beneficial in managing postoperative pain in dogs after laparoscopic surgeries. However, further research with a larger sample size is needed to confirm this and to determine if acetazolamide should be included in a multimodal postoperative analgesia protocol for laparoscopic ovariectomy in dogs.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/36952262/