Peer-reviewed veterinary case report
New type I feline coronavirus vaccine tested in mice and cats
By Zhou, Qun et al.·Published in Microbial pathogenesis·2024·College of Animal and Veterinary Sciences, China·View original on PubMed →
PetCaseFinder translated the abstract of this peer-reviewed paper into plain English so pet owners can read it. We do not publish original research — every detail traces back to the citation above. How we work →
Original publication title: Preparation of a novel type I feline coronavirus virus-like particle vaccine and its immunogenicity in mice and cats.
- Species:
- cat
Plain-English summary
A group of cats was vaccinated with a new type of feline coronavirus (FCoV) vaccine to see if it could help protect them from this serious illness. The vaccine showed promising results, as all vaccinated cats developed high levels of antibodies against the virus. Additionally, after a booster shot, some cats that had previously tested positive for FCoV showed a significant drop in the virus in their feces, and two cats even tested negative for the virus afterward. This new vaccine could be an effective way to prevent FCoV infections in cats.
People also search for: cat coronavirus vaccine · feline coronavirus symptoms · how to prevent cat coronavirus
Abstract
Feline coronavirus (FCoV) infection is a leading cause of death in cats. In this study, we produced FCoV-I virus-like particles (VLPs) containing E, M, N, and S proteins using a baculovirus expression system and mixed VLPs with the adjuvants MF59 and CpG 55.2 to prepare an VLP/MF59/CpG vaccine. After immunization of mice with the vaccine, IgG specific antibodies titers against S and N proteins increased to 1:12,800, and IFN-γand IL-4splenocytes were significantly increased. Following immunization of FCoV-negative cats, the S protein antibodies in immunized cats (5/5) increased significantly, with a peak of 1:12,800. Notably, after booster vaccination in FCoV-positive cats, a significant reduction in viral load was observed in the feces of partial cats (4/5), and the FCoV-I negative conversion was found in two immunized cats (2/5). Therefore, the VLP/MF59/CpG vaccine is a promising candidate vaccine to prevent the FCoV infection.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/39019122/