Peer-reviewed veterinary case report
Exercise collapse gene found in Labradors and some retriever breeds
By Minor, Katie M et al.·Published in Veterinary journal (London, England : 1997)·2011·Department of Veterinary Clinical Sciences, United States·View original on PubMed →
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Original publication title: Presence and impact of the exercise-induced collapse associated DNM1 mutation in Labrador retrievers and other breeds.
- Species:
- dog
Plain-English summary
A study found that many Labrador retrievers, especially those with a specific genetic mutation (DNM1), are at risk for exercise-induced collapse (d-EIC), which can cause them to suddenly collapse during physical activity. In fact, about 84% of Labradors with this mutation showed signs of collapsing by the age of four. This mutation was also found in other breeds like Chesapeake Bay retrievers and Pembroke Welsh corgis. It's important for pet owners and breeders to be aware of this condition, as it can affect dogs even if they don't look like retrievers.
People also search for: Labrador exercise collapse symptoms · DNM1 mutation in dogs · dog collapses during exercise · Chesapeake Bay retriever health issues · how to prevent exercise-induced collapse in dogs
Abstract
The impact of the mutation causing dynamin 1 (DNM1)-associated exercise-induced collapse (d-EIC) was determined in a retrospective genetic survey. The frequency of DNM1 mutant allele carriers in Labrador retrievers from conformation show, field trial/hunt test, pet or service lines ranged from 17.9% to 38.0% and the frequency of homozygous mutant (EE genotype) individuals ranged from 1.8% to 13.6%; 83.6% of these EE Labradors were reported to have collapsed by 4 years of age. DNM1 mutation carriers and EE dogs with a collapse phenotype were also detected in Chesapeake Bay retrievers, Curly-coated retrievers, Boykin spaniels, Pembroke Welsh corgis and mixed breed dogs thought to be Labrador retriever crosses. The DNM1 mutation was not identified in Golden, Flat-coated, or Nova Scotia duck tolling retrievers, or 15 other non-retrieving breeds. Veterinarians and breeders should be aware that the DNM1 EE genotype is not completely penetrant and that d-EIC is a widespread health concern in several very popular breeds, as well as breeds whose genetic similarity to retrievers is not obvious.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/21782486/