Peer-reviewed veterinary case report
Possible new Helicobacter pylori-like bacteria found in cat and dog
By Taillieu, Emily et al.·Published in Veterinary research·2023·Department of Pathobiology·View original on PubMed →
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Original publication title: Presence of potentially novel Helicobacter pylori-like organisms in gastric samples from cats and dogs.
- Species:
- dog
Plain-English summary
A study found that 83% of cats and dogs tested had signs of infection with certain types of Helicobacter bacteria in their stomachs. While some samples showed evidence of the well-known H. pylori, many had other similar bacteria that are not fully understood yet. The researchers noted that these bacteria might not be causing significant health problems for the pets. Further testing is needed to better understand these organisms and their effects on pets' health.
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Abstract
While seven gastric non-Helicobacter pylori Helicobacter (NHPH) species are known to commonly colonize the stomach of cats and dogs, the potential of H. pylori and H. pylori-like organisms to infect animals remains controversial and was investigated in this study using gastric samples of 20 cats and 27 dogs. A Helicobacter genus-specific 16 S rRNA PCR assay, H. pylori-specific ureAB and glmM PCR assays and a nested PCR detecting 23 S rRNA in a Helicobacter genus-specific manner in a first round of PCR and a H. pylori-specific manner in a second round, were performed in combination with sequencing. Histopathological and anti-Helicobacter immunohistochemical evaluations were also performed. Based on 16 S rRNA sequence analysis, 39/47 animals (83%) appeared infected with canine/feline gastric NHPHs in the corpus and/or antrum. H. pylori-specific ureAB amplicons were obtained in samples of 22 stomachs (47%). One canine antrum sample positive in the ureAB assay was also positive in the H. pylori-specific glmM assay. While 36/47 (77%) animals had a positive sample in the first round of the nested 23 S rRNA PCR assay, all samples were negative in the second round. Sequence analysis of obtained amplicons and immunohistochemistry point towards the presence of unidentified H. pylori-like organisms in cats and dogs. Histopathological examination suggests a low pathogenic significance of the gastric Helicobacter spp. present in these animals. In conclusion, cats and dogs may be (co-)infected with gastric Helicobacter organisms other than the known gastric NHPHs. Culture and isolation should be performed to confirm this hypothesis.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/37849010/