Peer-reviewed veterinary case report
Dog with fibrotic lung disease after bronchiolitis obliterans
By Jaffey, Jared A et al.Ā·Published in Frontiers in veterinary scienceĀ·2019Ā·Department of Veterinary Medicine and Surgery, United StatesĀ·View original on PubMed ā
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Original publication title: Presumptive Development of Fibrotic Lung Disease Fromand Post-infectious Bronchiolitis Obliterans in a Dog.
- Species:
- dog
Plain-English summary
A 7-month-old Miniature Poodle developed a cough and breathing problems after being acquired from a pet store. Despite treatment with antibiotics, the dog's symptoms only partially improved, leading to surgery to remove a part of the lung. Unfortunately, the dog continued to have respiratory issues over the years, and at 8 years old, a necropsy revealed severe lung damage. The findings suggest that a condition similar to post-infectious bronchiolitis obliterans, which is known in children, may have caused the dog's ongoing lung problems. This case highlights the need for further research into this condition in dogs and potential treatments.
People also search for: dog cough treatment Ā· Miniature Poodle breathing problems Ā· post-infectious bronchiolitis in dogs
Abstract
A 7-month-old Miniature Poodle acquired from a pet store developed cough and subsequently respiratory distress compatible withinfection. Partial but incomplete resolution of clinical signs and thoracic radiographic/computed tomographic imaging lesions were noted with use of susceptibility-guided antimicrobials. Additionally, a concern for an infectious nidus led to left cranial lung lobectomy at 9 months of age. Histopathology predominantly revealed polypoid and constrictive bronchiolitis obliterans (i.e., small airway disease). Intermittent antimicrobial administration over the next 5 years failed to blunt progressive clinical signs. At 8 years, necropsy confirmed severe airway-centered interstitial fibrosis. This pattern of fibrosis was strongly suggestive of underlying small airway disease as the trigger. In retrospect, post-infectious bronchiolitis obliterans (PIBO), a syndrome in young children caused by pulmonary infections but not yet recognized in pet dogs, likely initiated a pathway of fibrosis in this dog. In dogs with risk factors for community-acquired pathogens such as, PIBO is a differential diagnosis with development of severe, persistent respiratory signs incompletely responsive to appropriate antimicrobials. Untreated PIBO may lead to airway-centered interstitial fibrosis. Future study is required to determine if targeted therapy of PIBO could alter the course of end-stage pulmonary fibrosis.
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Search related cases āOriginal publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/31649945/