Peer-reviewed veterinary case report
Four dogs with bleeding ulcers after lornoxicam poisoning
By Karakitsou, Vicky et al.·Published in Topics in companion animal medicine·2021·Companion Animal Clinic·View original on PubMed →
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Original publication title: Presumptive Lornoxicam Intoxication in Four Dogs.
- Species:
- dog
Plain-English summary
Four dogs of different breeds, aged between 7 months and 10 years, were brought to the vet after eating a human pain medication called lornoxicam. They showed symptoms like black, tarry stools, lack of appetite, and lethargy within a few days of ingestion. Upon examination, the dogs had severe anemia and were found to have serious stomach ulcers. Three of the dogs needed extensive treatment, including blood transfusions and a hospital stay of up to 20 days, but they eventually recovered and were discharged.
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Abstract
Lornoxicam is a nonsteroidal anti-inflammatory drug extensively used in human medicine, which is not approved for canine use. Lornoxicam intoxication has been rarely reported in dogs. Four dogs of various breeds, aged 7 months to 10 years, were admitted with a recent history of melena, anorexia and depression, occurring 1-4 days after the ingestion of lornoxicam (dose range: 0.53-2.7 [median 1.17] mg/kg). No clinically relevant comorbidities were documented, but low doses of prednisolone had been given in 3 of the dogs, in close temporal association with lornoxicam. Major clinical and clinicopathologic findings on admission included mucosal pallor, melena, depression, severe anemia, neutrophilic leucocytosis, and panhypoproteinemia. Perforated pyloric and duodenal ulcers were documented in 3 dogs by exploratory celiotomy or postmortem. Prolonged hospitalization (5-20 days) with extensive supportive care and multiple blood transfusions was required in 3 of the 4 dogs who survived to discharge. Lornoxicam ingestion may cause protracted and severe gastrointestinal tract injury and bleeding, blood loss anemia, panhypoproteinemia, and perforated gastrointestinal ulcers, associated with significant morbidity and mortality in dogs.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/33249243/