Peer-reviewed veterinary case report
Young female dog with bladder inflammation turning into cancer
By Butty, Emmanuelle Marie et al.·Published in Journal of veterinary internal medicine·2021·Tufts University Cummings School of Veterinary Medicine, United States·View original on PubMed →
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Original publication title: Presumptive malignant transformation of chronic polypoid cystitis into an apical transitional cell carcinoma without BRAF mutation in a young female dog.
- Species:
- dog
Plain-English summary
A 3-year-old spayed female English Springer Spaniel was brought to the vet twice over four months because she was having blood in her urine and needing to urinate frequently. Initial tests showed inflammation in her bladder, but despite treatment, her symptoms returned. After eight months, a follow-up biopsy revealed that she had developed a type of bladder cancer called transitional cell carcinoma. The dog underwent surgery to remove part of her bladder, and it was noted that there were no mutations associated with this type of cancer. This case highlights the importance of monitoring dogs with bladder issues closely and considering surgery if they don’t improve with medication.
People also search for: dog blood in urine treatment · English Springer Spaniel bladder cancer · transitional cell carcinoma in dogs
Abstract
A 3-year-old spayed female English Springer Spaniel was presented twice 4 months apart for investigation of hematuria and pollakiuria without urinary tract infection. Both ultrasound examinations identified a stable craniodorsal bladder wall thickening. The first cystoscopic biopsy samples indicated lymphoplasmacytic cystitis and the second polypoid cystitis. The dog was represented 8 months later for recurrent clinical signs despite medical management. Although the ultrasound examination showed stable disease, repeat cystoscopic biopsy identified transitional cell carcinoma (TCC), confirmed on tissue removed by partial cystectomy. No BRAF mutation was ever detected in urine or tissue samples. To our knowledge, this case represents the first report of presumptive malignant transformation of polypoid cystitis into an apical TCC in a dog. Dogs with polypoid cystitis should be followed closely and surgical management considered if rapid resolution is not achieved with medical management.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/33739477/