Peer-reviewed veterinary case report
Dog with depression and pale gums diagnosed with rare leukemia
By Mylonakis, Mathios E et al.·Published in Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·2012·Companion Animal Clinic·View original on PubMed →
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Original publication title: Presumptive pure erythroid leukemia in a dog.
- Species:
- dog
Plain-English summary
A 6.5-year-old male Cocker Spaniel was brought to the vet because he was acting depressed and not eating for a week. During the exam, the vet noticed his gums were pale, which can indicate anemia. Blood tests showed he had low levels of red and white blood cells, and a bone marrow test revealed a high number of abnormal cells, suggesting a type of cancer called pure erythroid leukemia. Unfortunately, this condition is serious and often difficult to treat effectively.
People also search for: Cocker Spaniel depression and anorexia · dog leukemia symptoms · treatment for dog anemia
Abstract
A 6.5-year-old, intact male Cocker Spaniel dog was referred with a history of depression and anorexia of 1-week duration. Mucosal pallor was prominent on physical examination. Complete blood cell count revealed pancytopenia and occasional blast cells. Bone marrow aspirate cytology indicated that individual particles were composed of approximately 60% hematopoietic cells and a monomorphic population of blast cells with perfectly round nuclei, consistent paranuclear clearing, and deeply basophilic cytoplasm devoid of granules dominating the marrow fields. The granulocytic lineage was severely decreased with a granulocytic-to-erythroid ratio of 0.15 and a blast cell percentage of at least 70% of all nucleated cells; the myeloblasts and monoblasts composed <5% of nonerythroid cells. Bone marrow cytology slides were submitted for immunocytochemical immunophenotyping using antibodies to myeloperoxidase, cluster of differentiation (CD)3, CD79a, CD11b, CD45, and CD34. The neoplastic cells did not express any of the antigens assessed. The combination of light microscopic cytomorphology and the immunophenotype were strongly suggestive of pure erythroid leukemia.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/22807506/