Peer-reviewed veterinary case report
Dog vomited and turned yellow from trimethoprim-sulfadiazine liver
By Rowland, P H et al.·Published in Journal of the American Veterinary Medical Association·1992·Department of Pathology, United States·View original on PubMed →
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Original publication title: Presumptive trimethoprim-sulfadiazine-related hepatotoxicosis in a dog.
- Species:
- dog
Plain-English summary
A 5-year-old mixed-breed dog developed vomiting, loss of appetite, and yellowing of the skin and eyes after starting treatment with a medication called trimethoprim-sulfadiazine. Blood tests showed high liver enzyme levels, indicating liver stress. Once the medication was stopped, the dog's symptoms improved, and follow-up tests showed that the liver function returned to normal. A liver biopsy confirmed inflammation and bile buildup in the liver, but the dog recovered well after discontinuing the drug.
People also search for: dog vomiting after medication · dog liver problems symptoms · trimethoprim-sulfadiazine side effects in dogs
Abstract
Administration of trimethoprim-sulfadiazine in a dog was associated with vomiting, inappetence, and icterus, and high values of alanine transaminase, aspartate transaminase, alkaline phosphatase, gamma-glutamyltransferase, and total bilirubin concentration. The clinical signs and biochemical abnormalities resolved after discontinuation of the treatment. Histologic examination of sections from a liver biopsy specimen revealed moderate, predominantly portal hepatitis with cholestasis.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/1548170/