Peer-reviewed veterinary case report
Presynaptic Homeostatic Plasticity Staves off Neurodegenerative Pathophysiology up to a Tipping Point.
- Journal:
- Neuron
- Year:
- 2020
- Authors:
- Goldsmith, Juliet & Holzbaur, Erika L F
- Affiliation:
- Department of Physiology · United States
Abstract
In this issue of Neuron, Orr et al. (2020) identify an evolutionarily conserved mechanism of presynaptic homeostatic plasticity induced by ALS-like motor neuron degeneration, which maintains excitatory potentials until a threshold of synaptic loss is reached. Past this tipping point, disease onset progresses rapidly.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/32645308/