Peer-reviewed veterinary case report
Pretreatment white blood cell ratios predict survival in dogs
By Skor, O et al.·Published in Veterinary and comparative oncology·2017·Department for Companion Animals and Horses·View original on PubMed →
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Original publication title: Pretreatment leukocyte ratios and concentrations as predictors of outcome in dogs with cutaneous mast cell tumours.
- Species:
- dog
Plain-English summary
A group of 92 dogs with skin tumors called mast cell tumors (MCT) were studied to see if certain blood cell counts could predict their survival. The researchers found that specific ratios of white blood cells, particularly the neutrophil-to-eosinophil ratio and the relative eosinophil concentration, were linked to how well the dogs did after treatment. These findings suggest that checking these blood cell ratios could help veterinarians understand a dog's prognosis better.
People also search for: dog mast cell tumor prognosis · blood test results for dog cancer · what is a mast cell tumor in dogs
Abstract
Leukocyte ratios correlate with outcome in several human cancers. Little is known about their prognostic significance in mast cell tumour (MCT). The aim of the study was to evaluate the prognostic significance of pretreatment leukocyte concentrations and their ratios in dogs with MCT for survival. Medical records of 92 dogs with MCT were retrospectively reviewed. Tumour diagnosis was made by tumour biopsy or fine-needle aspirate. Only dogs without prior treatment were included. Eosinophil, lymphocyte, monocyte and neutrophil concentration were obtained by ADVIA 2120™ (Siemens Healthcare, Vienna, Austria). Neutrophil-to-eosinophil ratio (NER), lymphocyte-to-monocyte ratio (LMR) and neutrophil-to-lymphocyte ratio (NLR) were calculated from collected leukocyte concentrations. Relative eosinophil concentration (REC), NER (P < 0.001), NLR (P = 0.001) and LMR (P < 0.001) were significant prognostic factors for outcome in univariate analysis. REC (P = 0.008) and NER (P = 0.001) remained independent predictors of survival in multiple analyses. Leukocyte concentrations and ratios, especially REC and NER may serve as prognostic indicators in MCT.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/27723224/