Peer-reviewed veterinary case report
Patellar luxation affects 24% of Kooiker dogs with genetic links
By Wangdee, C et al.·Published in Veterinary journal (London, England : 1997)·2014·Department of Veterinary Surgery·View original on PubMed →
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Original publication title: Prevalence and genetics of patellar luxation in Kooiker dogs.
- Species:
- dog
Plain-English summary
A study found that about 24% of Dutch Kooiker dogs have patellar luxation, a condition where the kneecap slips out of place, causing limping or difficulty walking. This issue was equally common in both male and female dogs, and the condition was more often medial (toward the inside of the leg) than lateral (toward the outside). Over time, the prevalence of patellar luxation in this breed has decreased from 28% to 19% due to screening and breeding efforts. The research suggests that genetic factors may play a role, and better breeding practices could help reduce the occurrence of this condition in the future.
People also search for: Kooiker dog limping · patellar luxation treatment in dogs · Kooiker dog knee problems
Abstract
The prevalence of patellar luxation (PL) and genetic factors potentially involved in the disorder were investigated in Dutch Kooiker dogs. A cohort of 842 Kooiker dogs, the offspring of 195 sires and 318 dams, was screened for PL from 1994 to 2011. The cohort was included in a pedigree of 1737 Kooiker dogs comprising nine generations. PL was present in 24% of screened dogs, with unilateral and bilateral luxation being observed equally frequently. Medial PL was more common (61%) than lateral PL (32%) or bidirectional PL (7%). The frequency of PL was similar in male and female dogs, with a female:male relative risk of 1.15 (95% confidence interval, CI, 0.90-1.48). The heritability of PL in the screened population was 0.27 ± 0.07. Since the start of the screening programme, the prevalence of PL decreased from 28% to 19%. A genome-wide association study of PL with 48 cases and 42 controls suggested the possible involvement of a region on chromosome 3 (Praw = 1.32 × 10(-)(5), Pgenome = 0.142), but the involvement of this region could not be confirmed in a validation group. Breeding programmes for complex diseases, such as PL, would benefit from combining pedigrees, phenotypes and genotypes, i.e. from genomic selection, as is currently the method of choice for breeding of production animals.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/24986317/