Peer-reviewed veterinary case report
Autoantibodies found in cerebrospinal fluid of dogs with brain
By Matsuki, Naoaki et al.·Published in The Journal of veterinary medical science·2004·Department of Veterinary Clinical Pathobiology, Japan·View original on PubMed →
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Original publication title: Prevalence of autoantibody in cerebrospinal fluids from dogs with various CNS diseases.
- Species:
- dog
Plain-English summary
A group of dogs with various central nervous system (CNS) diseases had their cerebrospinal fluid (CSF) tested for specific autoantibodies. The tests showed that all dogs with necrotizing meningoencephalitis (NME) and most with granulomatous meningoencephalitis (GME) had these autoantibodies, which could help in diagnosing these serious conditions. Additionally, some dogs with brain tumors also tested positive for the autoantibody. This finding suggests that testing for these autoantibodies in CSF could be important for diagnosing certain CNS diseases in dogs.
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Abstract
To examine the prevalence of autoantibody in canine cerebrospinal fluids (CSFs), CSFs were collected from 14 healthy controls and 88 clinical cases with various diseases in the central nervous system (CNS), and were analyzed by an indirect fluorescence antibody test on frozen sections of the cerebrum from normal Beagle dogs. An anti-astrocyte autoantibody was detected in 31 clinical cases with titers ranging from 1:1 to >/=1:100. All tested cases with necrotizing meningoencephalitis (NME: n=22) and granulomatous meningoencephalitis (GME: n=3) possessed the anti-astrocyte autoantibody, while the autoantibody was negative in most cases with other inflammatory CNS diseases. The autoantibody was also detected in 4 of 12 cases with brain tumors. Hence, examination of the autoantibody in the canine CFS would be significant for diagnosing NME and/or GME, as well as for understanding peritumoral events in cases with brain tumors.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/15107560/