Peer-reviewed veterinary case report
Third-generation cephalosporin-resistant bacteria in dogs and cats
By Maeyama, Yoshihiko et al.·Published in Veterinary microbiology·2018·Department of Health and Medical Sciences, Japan·View original on PubMed →
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Original publication title: Prevalence of ESBL/AmpC genes and specific clones among the third-generation cephalosporin-resistant Enterobacteriaceae from canine and feline clinical specimens in Japan.
Plain-English summary
A study found that some dogs and cats in Japan had urinary tract infections caused by bacteria that are resistant to common antibiotics. Out of 487 samples, 104 showed resistance to third-generation cephalosporins, with a significant number being E. coli and Klebsiella pneumoniae. This resistance can make treating these infections more difficult for veterinarians. The findings highlight the importance of monitoring antibiotic resistance in pets, as they can carry these resistant bacteria, which may also affect humans.
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Abstract
In recent years, besides the widespread occurrence of extended-spectrum β-lactamase (ESBL)- and/or plasmid-mediated AmpC (pAmpC)-producing Enterobacteriaceae in both healthcare and community settings of humans, the third-generation cephalosporin (3GC)-resistant microbes have also been reported from companion animals worldwide. Here, we characterized ESBL- and/or pAmpC-producing Enterobacteriaceae clinical isolates from companion animals. Among the 487 clinical isolates mainly from urine of dogs and cats between May and September 2016, 104 non-repetitive isolates were resistant to the 3GC, and they consisted of 81 of 381 (21.3%) Escherichia coli, 21 of 50 (42.0%) Klebsiella pneumoniae, and 2 of 56 (3.6%) Proteus mirabilis isolates. In the 81 E. coli, the predominant bla genes were blaand bla(n = 15 each), followed by bla(n = 14), bla(n = 10), and bla(n = 5). In 21 K. pneumoniae, 10 bla gene types including bla(n = 4), bla(n = 4), and bla(n = 3) were found. The blawas identified in 2 P. mirabilis. Twenty-four of the 42 E. coli belonging to phylogroup B2 were O25b-ST131 clone, mostly associated with uropathogenic E. coli pathotype, and 22 isolates of this clone were identified as specific H30R subclone. High prevalence of the bla-harboring isolates were noted among the H30R/non-Rx lineage (13/19, 68.4%) (p <  0.05). The genetic environment of blaof most isolates of this lineage was identical to that of human isolates, but unique flanking genetic structures were also identified. Newly emerging virulent lineage B2-non-O25b-ST1193 was also confirmed in 5 isolates. The fosA3 and/or armA genes were detected in E. coli and K. pneumoniae isolates. These data suggest that companion animals serve as a potential reservoir of antimicrobial resistant E. coli and K. pneumoniae. This also has considerable veterinary importance, since urinary tract infections are an important disease causing therapeutic challenges worldwide.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/29519514/