Peer-reviewed veterinary case report
Toxin genes found in Staphylococcus pseudintermedius from dog skin
By Yoon, Jang W et al.·Published in Veterinary dermatology·2010·Konkuk University School of Medicine, South Korea·View original on PubMed →
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Original publication title: Prevalence of genes for enterotoxins, toxic shock syndrome toxin 1 and exfoliative toxin among clinical isolates of Staphylococcus pseudintermedius from canine origin.
- Species:
- dog
Plain-English summary
A study found that 74 samples of Staphylococcus pseudintermedius, a bacteria linked to skin infections and ear infections in dogs, were taken from 99 dogs with pyoderma (skin infections) or chronic ear infections. The researchers discovered that about 24% of these bacteria carried a specific toxin gene known as SEC(canine), which can contribute to illness. All samples also contained another toxin gene called SIET. Understanding how these toxins affect dog health could help improve treatments for conditions like skin and ear infections.
People also search for: dog skin infection treatment · chronic ear infection in dogs · Staphylococcus pseudintermedius in dogs
Abstract
A total of 74 Staphylococcus pseudintermedius strains were isolated from the 99 clinical cases of canine pyoderma or chronic otitis in our veterinary teaching hospital during May 2006-February 2008. In this study, we examined the genetic distribution of staphylococcal pyogenic toxins such as staphylococcal enterotoxins A (sea), B (seb), C (sec), D (sed), E (see), and toxic shock syndrome toxin 1 (tst) as well as the previously characterized S. intermedius exfoliative toxin (siet) among those isolates. The polymerase chain reaction analyses with the toxin gene-specific primers revealed that 18 (24.3%) of 74 S. pseudintermedius isolates carried the sec genes, but none of the sea, seb, sed, see and tst genes. Further DNA sequencing analysis of the amplified sec genes revealed that they all belonged to the canine type C staphylococcal enterotoxin (SEC(canine) ) whose superantigenic activity has been demonstrated. In addition to the sec(canine) genes, our polymerase chain reaction results showed that all the 74 isolates carried the siet gene. Since both SEC(canine) and SIET toxins are known to be biologically active, it would be interesting to investigate how those toxins are involved in the pathogenesis of the canine diseases by S. pseudintermedius such as pyoderma or chronic otitis.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/20500497/