Peer-reviewed veterinary case report
Low and high vitamin B12 levels in UK cats and what it means
By Borgonovi, Simona & Bayton, Will·Published in Journal of feline medicine and surgery·2025·Department of Internal Medicine, United Kingdom·View original on PubMed →
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Original publication title: Prevalence of hypocobalaminaemia and hypercobalaminaemia in a referral population of cats in the UK and its relevance to clinical presentation, diagnosis and prognosis.
- Species:
- cat
Plain-English summary
A group of cats was evaluated for low and high levels of vitamin B12 (cobalamin) to see how it affected their health. Out of 216 cats, 76 had low B12 levels, often showing symptoms like chronic vomiting and decreased appetite, while 67 had high B12 levels, with some experiencing chronic diarrhea. Many of the cats with low B12 had chronic enteropathy (a gut issue) and had a shorter survival time of about 9 months compared to over 2 years for those with high B12 levels. The study suggests that giving B12 supplements early may help improve outcomes for cats with low levels.
People also search for: cat chronic vomiting treatment · cat low vitamin B12 symptoms · cat high vitamin B12 causes
Abstract
ObjectivesThis study aimed to assess the prevalence of hypocobalaminaemia (B12 <400 pg/ml) and hypercobalaminaemia (B12 >1000 pg/ml), describe the clinicopathological abnormalities and the diagnostic imaging findings in a referral population of cats in the UK, and identify the underlying disease processes associated with both conditions.MethodsA retrospective study of cats that had their serum cobalamin concentration assessed between December 2016 and December 2023 at a single referral hospital; 216 cats were included. Patient outcome was established from the clinical records.ResultsA total of 76 (35%) cats had hypocobalaminaemia and 67 (31%) cats had hypercobalaminaemia. The most common diagnoses were chronic enteropathy (CE) in 39/76 (51%) hypocobalaminaemic cats and 39/67 (58%) hypercobalaminaemic cats ( = 0.001), and high-grade lymphoma in 14/76 (18%) hypocobalaminaemic cats and 11/67 (16%) hypercobalaminaemic cats ( = 0.438). The most common clinical signs were chronic vomiting in 36/76 (47%) hypocobalaminaemic cats and 24/67 (36%) hypercobalaminaemic cats ( = 0.005), hyporexia in 40/76 (53%) hypocobalaminaemic cats and 21/67 (31%) hypercobalaminaemic cats (<0.001), and chronic diarrhoea in 12/76 (16%) hypocobalaminaemic cats and 21/67 (31%) hypercobalaminaemic cats ( = 0.001). The most common abnormalities identified on abdominal ultrasound were lymphadenomegaly and thickened intestines in 49/76 (64%) hypocobalaminaemic cats and 28/67 (42%) hypercobalaminaemic cats ( = 0.0025). Median survival time was 274 days in the hypocobalaminaemic group and 711 days in the hypercobalaminaemic group ( = 0.001). The hypocobalaminaemic cats exhibited significantly reduced survival time compared with hypercobalaminaemic cats (odds ratio 2.4 vs 0.4, respectively) (<0.001).Conclusions and relevanceThis study suggests that cobalamin has limited diagnostic utility in differentiating between underlying disease processes; chronic diarrhoea and CE are more common in hypercobalaminaemic cats in contrast with the previous literature. Hypocobalaminaemia is associated with reduced survival in this cohort of cats; therefore, early cobalamin supplementation is recommended.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/40657883/