Peer-reviewed veterinary case report
High pancreas enzyme levels in puppies with parvovirus infection
By Kalli, Irida V et al.·Published in Veterinary clinical pathology·2017·Companion Animal Clinic·View original on PubMed →
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Original publication title: Prevalence of increased canine pancreas-specific lipase concentrations in young dogs with parvovirus enteritis.
- Species:
- dog
Plain-English summary
A group of 35 puppies with parvovirus enteritis were tested for a specific enzyme related to the pancreas, and about half had elevated levels. While these puppies showed higher enzyme activity, this did not seem to affect their recovery or how long they needed to stay in the hospital. The study found that even though many puppies had increased pancreatic enzyme levels, it didn't change the overall outcome of their illness. Most puppies recovered, but the presence of elevated enzyme levels didn't indicate a worse prognosis.
People also search for: puppy parvovirus treatment · elevated lipase in dogs · pancreatitis symptoms in puppies
Abstract
BACKGROUND: Pancreatic abnormalities during canine parvovirus (CPV) enteritis have not been studied prospectively. OBJECTIVES: The objective of this study was to evaluate the diagnostic significance of canine serum pancreas-specific lipase (Spec cPL) concentration in dogs with CPV enteritis for the presence of acute pancreatitis (AP). Puppies with naturally occurring CPV enteritis were recruited and prospectively allocated into 2 groups according to normal or increased serum Spec cPL concentration. Clinical signs, laboratory findings, and pancreas-associated variables were compared between groups, and the impact of possible AP on disease course, duration of hospitalization, and outcome was assessed. RESULTS: Serum Spec cPL concentration in 35 puppies was above the upper limit of the RI in 17/35 (48.6%) dogs (Group A) and within the RI in 18 dogs (Group B). An increased serum lipase activity was present in 29/35 (82.9%) dogs, and Group A dogs had a higher serum lipase activity than Group B (P = .006). Serum Spec cPL in Group A dogs was positively correlated with serum lipase activity at the day of presentation (r = .667; P = .003) and day of discharge (r = .628; P = .007). No statistically significant difference was found between groups (P = .233) for the presence of systemic inflammatory response syndrome (SIRS) (6/17 or 35.3% dogs Group A, and 8/18 or 44.4% dogs Group B), the disease course, duration of hospitalization, or outcome between groups. CONCLUSIONS: Increased serum Spec cPL is relatively common in dogs with CPV enteritis. However, such increases do not seem to correlate with the outcome of disease.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/28125171/