Peer-reviewed veterinary case report
Multidrug-resistant staph infections in dogs and cats with skin
By Burke, Mikaela & Santoro, Domenico·Published in Microbiology (Reading, England)·2023·Department of Small Animal Clinical Sciences, United States·View original on PubMed →
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Original publication title: Prevalence of multidrug-resistant coagulase-positive staphylococci in canine and feline dermatological patients over a 10-year period: a retrospective study.
Plain-English summary
A study found that many dogs and cats with skin problems had infections caused by antibiotic-resistant bacteria called coagulase-positive staphylococci (CPS). Over a 10-year period, a significant number of these pets tested positive for strains that were resistant to common antibiotics. Factors like previous antibiotic use and specific resistance markers were linked to these infections. The findings highlight the importance of careful antibiotic use and monitoring for resistant infections in pets with skin issues.
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Abstract
Coagulase-positive staphylococci (CPS) are common cutaneous pathogens often requiring multiple courses of antibiotics, which may facilitate selection for methicillin-resistant (MR) and/or multidrug-resistant (MDR) strains. To determine the prevalence of canine and feline MR/MDR CPS associated with skin diseases, medical records were retrospectively searched from April 2010 to April 2020. Pets with at least one positive culture for CPS were selected. Age, sex, antimicrobial sensitivity, previous history of antimicrobial/immunomodulatory medications and methicillin resistance/multidrug resistance status were recorded.(SP) (575/748) and(SS) (159/748) in dogs, and(12/22) in cats, were the most common CPS isolated. Three hundred and twenty-three out of 575 isolates were MR-SP (56.2 %), 304/575 were MDR-SP (52.8 %), 100/159 were MR-SS (62.9 %) and 71/159 were MDR-SS (44.6 %). A trend analysis showed a significant increase of resistance to oxacillin and chloramphenicol for(r=0.86, 0.8;=0.0007, 0.0034, respectively). Major risk factors for MDR-SP included oxacillin resistance (OR: 3; 95 % CI: 1.4-6.5;0.0044), positivity for PBP2a (OR: 2.3; 95 % CI: 1-5;0.031) and use of antibiotics in the previous year (OR: 2.8; 95 % CI: 1.3-5.8;=0.0071). Oxacillin resistance was identified as a major risk factor for MDR-SS (OR: 8.8; 95 % CI: 3.6-21.1;0.0001). These results confirmed the widespread presence of MR/MDR CPS in referred dermatological patients. Judicious antibiotic use, surveillance for MR/MDR infections and consideration of alternative therapies are crucial in mitigating the development of resistant strains.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/36786549/