Peer-reviewed veterinary case report
Pre-iridal membranes in dog eyes with congenital and other glaucoma
By Bedos, Leila et al.·Published in Frontiers in veterinary science·2024·Department of Veterinary Clinical Sciences, United States·View original on PubMed →
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Original publication title: Prevalence of pre-iridal monocellular and fibrovascular membranes in canine globes affected with congenital glaucoma associated with anterior segment dysgenesis, primary glaucoma associated with goniodysgenesis, and secondary glaucoma.
- Species:
- dog
Plain-English summary
A group of dogs with severe eye problems, including blindness and uncontrolled glaucoma, had their eyes removed for further examination. Researchers found that pre-iridal monocellular membranes, which can affect vision, were present in many of these dogs, especially those with primary glaucoma. Fibrovascular membranes were also seen but were less common. The study showed that these membranes are frequent in dogs suffering from different types of glaucoma, but they did not find any links between the type of membrane and the dog's breed, gender, or age.
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Abstract
OBJECTIVES: The objectives of this study were to (i) evaluate the prevalence of pre-iridal monocellular and fibrovascular membranes in canine globes affected with congenital glaucoma associated with anterior segment dysgenesis (ASD), primary glaucoma associated with goniodysgenesis (GD), and secondary glaucoma, and (ii) examine the associations between monocellular and fibrovascular membranes by breed, gender, age and histopathologic ocular changes on light microscopic examination. METHODS: Records of dogs who had eyes enucleated due to blindness and uncontrolled glaucoma were reviewed. Glaucoma was categorized clinically and histologically into three groups: congenital/ASD, primary/GD, and secondary glaucoma. The presence or absence and type of pre-iridal membrane (monocellular or fibrovascular) and other intraocular histologic findings were reviewed and compared statistically for each group. RESULTS: In total, 108 canine globes (101 dogs) were included. Pre-iridal monocellular membranes were identified with light microscopy in 10 out of 19 congenital/ASD, 29 out of 40 primary, and 23 out of 49 secondary glaucoma globes. Fibrovascular membranes were observed in 3 out of 19 congenital/ASD, 9 out of 40 in primary, and 24 out of 49 secondary glaucoma globes. There were no associations between the type of membrane and breed, gender, or age. Peripheral anterior synechiae were more common in globes with fibrovascular membranes, and uveal atrophy was more common in globes with monocellular membranes. CONCLUSION: Pre-iridal monocellular membranes are common in all types of canine glaucoma. They are identified with light microscopy most easily in cases of primary glaucoma, and they are masked by pre-iridal fibrovascular membranes in other forms of glaucoma.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/38444777/