Peer-reviewed veterinary case report
Prevention of endotoxin-induced arterial hypoxaemia and lactic acidosis with flunixin meglumine in the conscious pony.
- Journal:
- Equine veterinary journal
- Year:
- 1981
- Authors:
- Moore, J N et al.
Abstract
Bacterial endotoxin injected intravenously into conscious ponies produced alterations in cardiopulmonary and gastrointestinal function. Specifically, tachypnoea, dyspnoea, hypoxaemia, colic, lactic acidosis and diarrhoea resulted from administration of 10 micrograms/kg Escherichia coli endotoxin. Pretreatment of the ponies with a potent prostaglandin synthetase inhibitor, flunixin meglumine, prevented these ill effects of endotoxin.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/7018898/