Peer-reviewed veterinary case report
Prevention of tissue injury in an ascending mouse model of chronic pyelonephritis--role of free radical scavengers.
- Journal:
- Comparative immunology, microbiology and infectious diseases
- Year:
- 2004
- Authors:
- Gupta, R et al.
- Affiliation:
- Department of Microbiology · India
Abstract
The role of free radical scavengers in preventing the tissue injury using a non obstructive, ascending mouse model for chronic pyelonephritis was assessed. The parameters taken into consideration are Luminol Dependent Chemiluminescence (LDCL), histopathology and some biochemical investigations. We have observed that both catalase and Dimethyl-Sulfoxide (DMSO, free radical scavengers) were able to prevent the free radical mediated tissue injury and ultimate renal scarring, irrespective of the bacterial strain studied.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/15177997/