Peer-reviewed veterinary case report
Blindness from nerve sheath tumor in both dog corneas
By Leis, Marina L et al.·Published in Veterinary ophthalmology·2017·Department of Small Animal Clinical Sciences, Canada·View original on PubMed →
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Original publication title: Primary bilateral corneal nerve sheath neoplasm in a dog.
- Species:
- dog
Plain-English summary
A 15-year-old neutered male Shih Tzu cross developed thickening and abnormal blood vessel growth in both eyes, leading to blindness. After five months, both eyes were so affected that they had to be removed. A detailed examination revealed that the problem was caused by a rare type of tumor in the cornea, specifically a nerve sheath sarcoma. Unfortunately, this case highlights a serious condition that can occur in older dogs, and treatment involved the surgical removal of the eyes to prevent further complications.
People also search for: dog eye problems · Shih Tzu blindness treatment · corneal tumor in dogs
Abstract
A 15-year-old, neutered male, Shih Tzu cross developed progressive corneal stromal thickening and vascularization of the right eye, and 5 months later, of the left eye. Both eyes became blind due to extensive corneal opacification and were enucleated. Light microscopic examination revealed a diffuse corneal infiltrate of neoplastic mesenchymal cells, and immunohistochemistry revealed diffuse cytoplasmic vimentin immunoreactivity and variable cytoplasmic and nuclear immunoreactivity for S100 in the neoplastic cells. Transmission electron microscopy revealed desmosomes between contiguous cells, thread-like cytoplasmic processes coated with basement membrane, extracellular bundles of collagen, and axonal degeneration consistent with features of a nerve sheath neoplasm. This is the first report of primary, bilateral corneal nerve sheath sarcoma in a canine.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/27352771/