Peer-reviewed veterinary case report
Primary ciliary dyskinesia causing lung infections in Newfoundland
By Watson, P J et al.·Published in The Veterinary record·1999·View original on PubMed →
PetCaseFinder translated the abstract of this peer-reviewed paper into plain English so pet owners can read it. We do not publish original research — every detail traces back to the citation above. How we work →
Original publication title: Primary ciliary dyskinesia in Newfoundland dogs.
- Species:
- dog
Plain-English summary
Three Newfoundland dogs were diagnosed with primary ciliary dyskinesia, a condition that affects their ability to clear mucus from their airways, leading to chronic nasal and lung infections. These dogs showed symptoms like chronic rhinitis and bronchopneumonia from a young age, with severe lung issues found on X-rays and examinations. Unfortunately, one dog died at just over five years old, another was euthanized at nine months, and only one is still alive. This genetic condition appears to be inherited and is the first of its kind reported in this breed.
People also search for: Newfoundland dog breathing problems · chronic bronchopneumonia in dogs · primary ciliary dyskinesia symptoms in dogs
Abstract
Primary ciliary dyskinesia was diagnosed in three Newfoundland dogs with histories of chronic rhinitis and bronchopneumonia from an early age. Thoracic radiographs of two of them showed severe, dependent bronchopneumonia and right displacement of the cardiac apex but normal positioning of other organs. Histopathological examination of sections of lung from the other dog showed severe bronchopneumonia. A semen sample from one dog had a high percentage of spermatozoa with abnormal tails and poor progressive motility. Transmission electron microscopy of nasal brushings from all three dogs showed consistent ultrastructural defects in the cilia, including an absence of outer and inner dynein arms, disorganisation of peripheral doublets, occasional supernumerary doublets and singlets, and consistently disorganised basal bodies and foot processes; sections of trachea from one dog also had disorganised basal bodies. Pedigree analysis was consistent with a monogenic autosomal recessive pattern of inheritance for the defect. One dog is still alive, one dog died aged five years two months, and one dog was euthanased aged nine months. This is the first time primary ciliary dyskinesia has been reported in Newfoundland dogs.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/10423815/